Coronavirus vaccine triggers immune response in mice
On March 11, 2020, the planet Health Organization designated COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, a world pandemic. By April 6, the disease had infected over 1,000,000 people round the world. quite 70,000 have died. Treatments and vaccines for COVID-19 are urgently needed to reverse the tide of this pandemic.
After the identification of SARS-CoV-2, the genome sequence of the new coronavirus was rapidly released to the general public by scientists in China. Several weeks later, NIH-funded scientists produced an in depth picture of the a part of the virus, called the spike protein, that permits it to infect human cells. Researchers led by Drs. Louis Falo,
Jr. and Andrea Gambotto from the University of Pittsburgh are working to develop vaccines for other coronaviruses, including the one that causes Middle East systema respiratorium (MERS). They adapted the system that they had been developing to supply a candidate MERS vaccine to rapidly produce an experimental vaccine using the SARS-CoV-2 spike protein. The study was funded by NIH’s National Institute of Allergy and Infectious Diseases (NIAID),
Coronavirus
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and National Cancer Institute (NCI). It appeared online on April 1, 2020, in EBioMedicine, a Lancet journal. The team developed a way for delivering their MERS vaccine into mice employing a microneedle patch. Such patches resemble a bit of Velcro, with many tiny microneedles made from sugar. The needles prick just into the skin and quickly dissolve, releasing the vaccine. Since the system is very active within the skin, delivering vaccines this manner may produce a more rapid and robust immune reaction than standard injections under the skin. When delivered by microneedle patch to mice,
Three different experimental MERS vaccines induced the assembly of antibodies against the virus. These responses were stronger than the responses generated by regular injection of 1 of the vaccines along side a strong immune stimulant (an adjuvant). Antibody levels continued to extend over time in mice vaccinated by microneedle patch—up to 55 weeks,
When the experiments ended. Using knowledge gained from development of the MERS vaccine, the team made an identical microneedle vaccine targeting the spike protein of SARS-CoV-2. The vaccine prompted robust antibody production within the mice within fortnight . The vaccinated animals haven’t been tracked for enough time to ascertain if the long-term immune reaction is like that observed with the MERS vaccines. The mice have also not yet been challenged with
SARS-CoV-2 infection. The components of the experimental vaccine might be made quickly and at large-scale, the researchers say. the ultimate product also doesn’t require refrigeration, so it might be produced and placed in storage until needed. The team has now begun the method of obtaining approval from the U.S. Food and Drug Administration to launch a phase 1 trial within subsequent several months. Much work still must be done to explore the security and efficacy of this candidate vaccine. “This particular situation is different from anything we’ve ever seen, so we don’t skills long the clinical development process will take.”
After the identification of SARS-CoV-2, the genome sequence of the new coronavirus was rapidly released to the general public by scientists in China. Several weeks later, NIH-funded scientists produced an in depth picture of the a part of the virus, called the spike protein, that permits it to infect human cells. Researchers led by Drs. Louis Falo,
Jr. and Andrea Gambotto from the University of Pittsburgh are working to develop vaccines for other coronaviruses, including the one that causes Middle East systema respiratorium (MERS). They adapted the system that they had been developing to supply a candidate MERS vaccine to rapidly produce an experimental vaccine using the SARS-CoV-2 spike protein. The study was funded by NIH’s National Institute of Allergy and Infectious Diseases (NIAID),
Coronavirus
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and National Cancer Institute (NCI). It appeared online on April 1, 2020, in EBioMedicine, a Lancet journal. The team developed a way for delivering their MERS vaccine into mice employing a microneedle patch. Such patches resemble a bit of Velcro, with many tiny microneedles made from sugar. The needles prick just into the skin and quickly dissolve, releasing the vaccine. Since the system is very active within the skin, delivering vaccines this manner may produce a more rapid and robust immune reaction than standard injections under the skin. When delivered by microneedle patch to mice,
Three different experimental MERS vaccines induced the assembly of antibodies against the virus. These responses were stronger than the responses generated by regular injection of 1 of the vaccines along side a strong immune stimulant (an adjuvant). Antibody levels continued to extend over time in mice vaccinated by microneedle patch—up to 55 weeks,
When the experiments ended. Using knowledge gained from development of the MERS vaccine, the team made an identical microneedle vaccine targeting the spike protein of SARS-CoV-2. The vaccine prompted robust antibody production within the mice within fortnight . The vaccinated animals haven’t been tracked for enough time to ascertain if the long-term immune reaction is like that observed with the MERS vaccines. The mice have also not yet been challenged with
SARS-CoV-2 infection. The components of the experimental vaccine might be made quickly and at large-scale, the researchers say. the ultimate product also doesn’t require refrigeration, so it might be produced and placed in storage until needed. The team has now begun the method of obtaining approval from the U.S. Food and Drug Administration to launch a phase 1 trial within subsequent several months. Much work still must be done to explore the security and efficacy of this candidate vaccine. “This particular situation is different from anything we’ve ever seen, so we don’t skills long the clinical development process will take.”
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